Drug intelligence / Profile preview

PF-07960613

Development stage
Phase 2
Lead developer
Pfizer
Modality
Recombinant Proteins and Enzymes, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

PF-07960613 is an investigational admixed combination vaccine developed by Pfizer, designed to provide simultaneous protection against respiratory syncytial virus (RSV) and COVID-19. The vaccine candidate comprises two distinct components: RSVpreF, a bivalent protein subunit vaccine containing stabilized prefusion F antigens from RSV-A and RSV-B subgroups, and a bivalent formulation of BNT162b2, an mRNA vaccine encoding the SARS-CoV-2 spike protein from the original strain and Omicron BA.4/BA.5 variants. By combining these antigens into a single immunization regimen, the candidate aims to simplify vaccination schedules for older adults (aged 65 and older) and reduce the overall burden of respiratory infections. It has been evaluated in Phase 1/2 clinical trials to assess its safety, tolerability, and immunogenicity compared to individual administrations.

Other names
RSVpreF + bivalent BNT162b2RSVpreF + BNT162b2RSV-COVID-19 combination vaccineRSV-COVID19 combination vaccineRSV-COVID 19 combination vaccine
02

Targets

SARS-CoV-2 spikeRSV F (Respiratory syncytial virus fusion protein)

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