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PF-07960613 + quadrivalent influenza vaccine
- Development stage
- Discontinued
- Lead developer
- Pfizer
- Modality
- Recombinant Proteins and Enzymes, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
PF-07960613 + quadrivalent influenza vaccine is a combination vaccine regimen developed by Pfizer. It consists of PF-07960613—a bivalent combination of the mRNA-based COVID-19 vaccine (BNT162b2; Comirnaty) and the recombinant RSV prefusion F protein subunit vaccine (RSVpreF; Abrysvo)—co-administered with a licensed quadrivalent influenza vaccine (QIV). The regimen was designed to provide comprehensive seasonal protection against three major respiratory viruses: SARS-CoV-2, Respiratory Syncytial Virus (RSV), and Influenza A and B. It was evaluated in Phase 2 clinical trials in healthy adults aged 65 and older to assess safety, tolerability, and immunogenicity. In July 2024, Pfizer announced the discontinuation of the PF-07960613 combination program, although the individual component vaccines remain available for their respective indications.
- Brand names
- AbrysvoComirnaty
- Other names
- QIV-Pfizer-COVID-19-Respiratory Syncytial Virus InfectionsQIV-Pfizer-COVID19-Respiratory Syncytial Virus InfectionsQIV-Pfizer-COVID 19-Respiratory Syncytial Virus InfectionsPfizer COVID-19-RSV-flu combination
02
Targets
SARS-CoV-2 spikeRSV F (Respiratory syncytial virus fusion protein)HA0 (Influenza B virus hemagglutinin)
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