PF-07976016-87

PF-07976016-87 is an investigational, long-acting Growth Differentiation Factor 15 (GDF15) analog developed by Pfizer for the treatment of obesity and overweight. GDF15 is a stress-induced cytokine and a member of the transforming growth factor-beta (TGF-β) superfamily that plays a critical role in energy homeostasis and body weight regulation. PF-07976016-87 acts as a potent agonist of the GDNF family receptor alpha-like (GFRAL), a highly specific receptor expressed exclusively in the hindbrain, specifically within the area postrema and the nucleus of the solitary tract. Upon binding to GFRAL and its signaling co-receptor RET, the drug activates neural pathways that suppress appetite and reduce food intake, particularly for calorie-dense foods. By mimicking the natural weight-regulatory effects of GDF15 with an optimized pharmacokinetic profile, PF-07976016-87 is designed to provide sustained weight reduction in patients with metabolic disorders.