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PF-07985045 + PF-07284892

Development stage: Unknown
Lead developer: Pfizer
Modality: Small Molecules
Administration: Oral, Intravenous

Overview

PF-07985045 + PF-07284892 is a combination investigational therapy being evaluated in Phase 1 clinical trials for the treatment of advanced solid tumors, including colorectal cancer and other KRAS mutation-related tumors. PF-07985045 is a small molecule inhibitor targeting KRAS, while PF-07284892 is a small molecule inhibitor targeting SHP2 (Src homology phosphotyrosyl phosphatase 2). The combination aims to overcome bypass signaling mechanisms and drug resistance in tumors where neither agent is effective as a single agent. Both drugs are orally administered and developed by Pfizer[1][2][3][4][5][7][9].

Targets

PTPN11 (Tyrosine-protein phosphatase non-receptor type 11)KRAS (Kirsten rat sarcoma viral oncogene homolog)

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