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Target intelligence / Profile preview
Kirsten rat sarcoma viral oncogene homolog (KRAS)
- Target
- KRAS
- Molecular classification
- Small GTPase, RAS protein family
01
Overview
KRAS encodes a small membrane-associated protein acting as a central node for transmitting growth factor signals from outside the cell into key intracellular signaling cascades controlling proliferation. Its function depends on regulated cycling between inactive GDP-bound and active-GTP bound states—a process disrupted by oncogenic mutations that drive many human cancers through persistent activation of mitogenic/survival pathways.
- Other names
- c-K-ras2Ki-Ras2KRAS2RASK2
02
Mechanism of action
Inhibition of KRAS G12C mutant
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalMetabolism regulation
04
Disease associations
CancerDevelopmental syndromes
05
Safety considerations
Resistance to targeted therapiesLack of effective therapies for non-G12C mutationsToxicity of KRAS inhibitors
06
Interacting drugs
Sotorasib
07
Biomarkers
KRAS mutation status (e.g., G12C, G12D, G12V)KRAS expression levels
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