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PF-08656795
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
PF-08656795 (MET-815i) is an investigational biologic agent developed by Pfizer for chronic weight management. It functions as an agonist of the GDNF family receptor alpha-like (GFRAL), which is the high-affinity receptor for Growth Differentiation Factor 15 (GDF15). By activating the GFRAL-RET signaling complex in the hindbrain, specifically within the area postrema and nucleus of the solitary tract, the drug is intended to reduce food intake and promote weight loss. PF-08656795 is engineered as a long-acting therapy to allow for infrequent dosing. It is currently in Phase 1 clinical development to evaluate its safety, tolerability, and pharmacokinetics in individuals with obesity.
02
Targets
GFRAL (Glial-derived neurotrophic factor family receptor alpha-like/ret receptor complex)
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