PfAMA1-FVO

PfAMA1-FVO is a recombinant protein vaccine candidate designed to prevent *Plasmodium falciparum* malaria. It consists of the ectodomain (amino acids 25–545) of the Apical Membrane Antigen 1 (AMA1) derived from the FVO (Falcetti/Vietnam/Oak Knoll) strain of the parasite. Expressed in the yeast *Pichia pastoris*, the protein is typically formulated with an adjuvant such as Alhydrogel. AMA1 is a microneme protein essential for the invasion of host erythrocytes; it interacts with Rhoptry Neck Protein 2 (RON2) to facilitate the formation of a moving junction during parasite entry. The vaccine aims to induce high titers of neutralizing antibodies that block this interaction, thereby inhibiting the parasite's life cycle at the blood stage.

Other names

AMA1-FVOAMA-1-FVOAMA 1-FVOPlasmodium falciparum apical membrane antigen 1 FVO strainrecombinant PfAMA1-FVO