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PG-033 is an investigational small molecule drug developed by Beijing Puqi Pharmaceutical Technology. It is currently in early clinical development, with its highest global R&D status being Phase 1. The primary indication under investigation for PG-033 is pruritus (itch), a symptom associated with various skin and musculoskeletal diseases. The drug is being evaluated for its safety, tolerability, and pharmacokinetics in healthy adults through single ascending dose studies and food effect studies. As of June 2025, there are no publicly available details on the specific molecular target or mechanism of action for PG-033[1][2][3][4].
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