PG-NSA

PG-NSA (Polyglycerol-based Nanostructured Organic Sheet) is a synthetic, two-dimensional nanomaterial designed as a therapeutic platform to treat radiation-induced mucositis. These nanosheets are functionalized with CD63-targeting aptamers, which allow them to selectively capture and sequester small extracellular vesicles (sEVs) released by damaged tissues. By removing these vesicles, which carry inflammatory triggers such as double-stranded DNA, PG-NSA prevents the activation of the STING (stimulator of interferon genes) pathway in macrophages, thereby suppressing excessive inflammation. Additionally, the polyglycerol structure of the nanosheet inherently scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS), providing a multi-modal anti-inflammatory effect. Its unique sheet-like geometry offers a significantly higher surface area and binding capacity for vesicles compared to traditional spherical nanoparticles.

Other names

Polyglycerol-based nanostructured organic sheetAptamer-functionalized polyglycerol nanostructured organic sheet