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PG014
- Development stage
- Preclinical
- Lead developer
- PersonGen BioTherapeutics
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
01
Overview
PG014 is a multispecific natural killer (NK) cell engager (NKCE) being developed by PersonGen-Anke Cellular Therapeutics for the treatment of autoimmune diseases. The therapeutic is designed to simultaneously engage CD16A on NK cells and target both PD-1 and an additional undisclosed target on pathogenic immune cells. This mechanism is intended to induce 'T-B double depletion,' effectively removing auto-reactive T and B cell populations to provide broad coverage across various autoimmune indications. Currently in the preclinical stage, PG014 represents a novel approach in the field of multispecific biologics for immune-mediated disorders.
02
Targets
FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)PDCD1 (Programmed cell death protein 1 receptor)
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