PGC-01

PGC-01: sourced facts only. name: "Through rational design of linkers and systematic optimization of the E3 ligase attachment site, we constructed a series of PROTACs and identified PGC-01 as a CRBN-recruiting and effective GSDMD degrader (DC50 = 3.32 μM, Dmax = 85%)." [PMID:42691697]; target: "Through rational design of linkers and systematic optimization of the E3 ligase attachment site, we constructed a series of PROTACs and identified PGC-01 as a CRBN-recruiting and effective GSDMD degrader (DC50 = 3.32 μM, Dmax = 85%)." [PMID:42691697]; developer: "School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China." [PMID:42691697]; modality: "Through rational design of linkers and systematic optimization of the E3 ligase attachment site, we constructed a series of PROTACs and identified PGC-01 as a CRBN-recruiting and effective GSDMD degrader (DC50 = 3.32 μM, Dmax = 85%)." [PMID:42691697]; stage: "In vivo, rectal administration of PGC-01 dose-dependently alleviated clinical symptoms and pathological damage in a DSS-induced murine colitis model." [PMID:42691697]