PGH2-A

PGH2-A is a stable, synthetic 9-methylene ether analogue of prostaglandin H2 (PGH2), chemically identified as 9,11-dideoxy-9α,11α-epoxymethanoprostaglandin F2α (U-44069). It functions as a potent agonist of the thromboxane A2 (TP) receptor, mimicking the biological activity of endogenous cyclic endoperoxides. PGH2-A is primarily utilized as a pharmacological research tool to investigate vascular and airway smooth muscle responses. In experimental models, such as unanesthetized sheep, it has been shown to induce significant, dose-dependent pulmonary vasoconstriction and increased pulmonary vascular resistance without affecting vascular permeability or systemic hemodynamics. Its high potency—approximately 100-fold greater than PGE2 or PGF2α in certain preparations—makes it a valuable reagent for studying the mechanisms of pulmonary hypertension and the role of thromboxane mimetics in physiological systems.

Other names

9,11-epoxymethano-PGH29,11-dideoxy-9a,11a-epoxymethanoprostaglandin F2a9-methylene ether analogue of PGH29,11-methanoepoxy-PGH2