Drug intelligence / Profile preview

PH100

Development stage
Phase 1
Lead developer
Phloronol
Modality
Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Intranasal, Oral
01

Overview

**PH100** is an investigational, orally administered standardized extract of purified phlorotannins derived from the brown alga *Ecklonia cava*, developed by Phloronol. Its characterized major constituents include 8,8'-bieckol, dieckol, and phlorofucofuroeckol A. In a completed randomized, double-blind, placebo-controlled single-ascending-dose Phase 1 study in healthy adults, PH100 capsules were evaluated at doses from 100 mg to 1,600 mg for safety, tolerability, and pharmacokinetics. No specific molecular therapeutic target or validated clinical mechanism of action was established in the available trial record. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04335045))

Other names
Ecklonia cava phlorotanninspurified Ecklonia cava phlorotannins

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