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Phage-Shahid Beheshti University of Medical Sciences-urinary tract infection
- Development stage
- Unknown
- Lead developer
- Shahid Beheshti University of Medical Sciences
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Intravesical
01
Overview
An investigational bacteriophage therapy being developed by Shahid Beheshti University of Medical Sciences for the treatment of chronic relapsing urinary tract infections (UTIs). [2] It is being evaluated in a Phase 3 clinical trial for UTIs caused by extended-spectrum beta-lactamase (ESBL)-positive Enterobacteriaceae in renal transplant recipients. Bacteriophages are viruses that specifically infect and destroy bacteria through lysis, offering a potential alternative to conventional antibiotics, particularly in cases of multidrug-resistant infections. [2, 5, 8] The therapy is administered directly into the bladder via intravesical instillation. [1, 2]
- Other names
- bacteriophages
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