Drug intelligence / Profile preview

Phalaris arundinacea pollen

Development stage
Unknown
Lead developer
ALK Abelló
Administration
Intradermal, Percutaneous, Subcutaneous, Sublingual
01

Overview

Phalaris arundinacea pollen is an allergenic extract derived from the pollen of reed canary grass, a perennial C3 grass widely distributed in temperate regions. It is utilized clinically for the diagnosis and treatment of grass pollen-induced allergic diseases, such as seasonal allergic rhinitis, allergic conjunctivitis, and allergic asthma. The extract contains a complex mixture of proteins, including Group 1 and Group 5 grass allergens, which are recognized by IgE antibodies in sensitized individuals. In diagnostic applications, such as skin prick testing, the extract induces mast cell degranulation and a subsequent wheal-and-flare reaction. In allergen immunotherapy (AIT), repeated administration of the extract at increasing doses aims to modify the underlying immune response, promoting the development of regulatory T cells (Tregs) and the production of IgG4 blocking antibodies, thereby inducing long-term clinical tolerance.

Other names
Reed canary grass pollenReed canary grass allergenic extract
02

Targets

IgE (Immunoglobulin E)

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