Drug intelligence / Profile preview

phanquinone

Development stage
Discontinued
Lead developer
Novartis
Modality
Small Molecules
01

Overview

Phanquinone is a synthetic small molecule belonging to the o‑quinones class, specifically derived by oxidation of 4,7‑phenanthroline. It has been investigated primarily as an antiprotozoal agent and for its bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Its mechanism of action is not fully elucidated but is thought to involve the generation of reactive oxygen species leading to oxidative stress in target cells. Historically used for amoebic and bacillary dysentery, it has also been explored for broader anti-infective applications[1][2][3][4][5][9].

Brand names
EntrononEntobexEnthohex
Other names
phanquonefanquinonaPhanquinone [INN]4,7-Phenanthroline-5,6-dione4,7-Phenanthrolene-5,6-dionePhanchinonePhanquinonumPhanchinonum
02

Targets

NR (Nuclear receptors (steroid))

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