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**PharmAla-1** is a novel chemical entity (NCE) in the MDXX class of molecules, developed by PharmAla Biotech as the first output of their computational drug development pipeline. It is a patented MDMA analog designed to improve safety properties over the base MDMA molecule for potential use in treating neurological and psychiatric disorders. Preclinical research is ongoing, with proof-of-concept studies initiated, and it has received US Patent Prosecution Highway acceptance and first office action for PCT filing. PharmAla-1 is not classified as a controlled substance worldwide.[7][16][18][22]
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