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Phenaridine is a synthetic opioid analgesic and a structural derivative of fentanyl. It was developed in 1972 and is primarily used for surgical anesthesia in Russia. Phenaridine acts as an agonist at the mu-opioid receptor (MOR), producing potent analgesic effects similar to fentanyl but with somewhat lower potency according to animal studies. Like other opioids in this class, its side effects include itching, nausea, and potentially life-threatening respiratory depression. Fentanyl analogs such as phenaridine have been associated with significant morbidity and mortality due to their high potency and risk of overdose[9].
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