phenazine methosulfate

Phenazine methosulfate (PMS) is a polycyclic aromatic redox mediator and electron carrier primarily utilized as a research reagent in biochemical assays, such as tetrazolium-based cell viability tests (e.g., MTT, XTT). Beyond its role in electron transfer, PMS has been identified as a pharmacological inhibitor of Serine Racemase (SRR), the enzyme responsible for the synthesis of D-serine from L-serine. In the context of oncology research, particularly glioblastoma (GBM), PMS is used to modulate the tumor microenvironment by reducing D-serine levels. This inhibition disrupts the interaction between GBM cells and host endothelial cells, specifically by preventing the D-serine-mediated activation of endothelial N-methyl-D-aspartate receptors (NMDARs), thereby suppressing tumor cell migration, stemness, and aggressive progression.

Other names

N-methylphenazonium methyl sulfate5-methylphenazinium methyl sulfateN-methylphenazinium methylsulfate