phencynonate hydrochloride

Phencynonate hydrochloride is a small molecule anticholinergic drug structurally similar to scopolamine, developed primarily for the prevention of motion sickness and treatment of vertigo[2][5][7]. It acts as an antagonist at both muscarinic and nicotinic acetylcholine receptors, with additional anti-NMDA properties[2][6]. The S-isomer (levophencynonate) has higher affinity for muscarinic acetylcholine receptors in the cerebral cortex and demonstrates greater efficacy against motion sickness without anxiogenic effects at therapeutic doses[2]. Phencynonate crosses the blood-brain barrier, protects against glutamate toxicity, exhibits neuroprotective effects in animal models of soman poisoning, and shows antidepressant activity by modulating dendritic spine density and NMDA receptor subunits in brain regions associated with mood regulation[2][3][6]. It has been investigated for use in motion sickness, vertigo, ischemic stroke, brain infarction, and depression; development status varies by indication.

Brand names

苯环壬酯片Prifinium Bromide Tablets

Other names

phencynonate hydrochloride3-Methyl-3-azabicyclo(3.3.1)nonanyl-9-alpha-yl-alpha-cyclopentyl-alpha-phenyl-alpha-glycolate hydrochlorideLevophencynonateLevo phencynonate hydrochloride