Drug intelligence / Profile preview

Phendimetrazine

Development stage
Approved
Lead developer
Virtus Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

Phendimetrazine is a sympathomimetic amine, chemically related to amphetamines, primarily used as a short-term appetite suppressant for the management of exogenous obesity. It functions as a prodrug, being metabolized in the liver to its active form, phenmetrazine. Its therapeutic effect is achieved by stimulating the release of norepinephrine and dopamine in the brain, particularly in the hypothalamus, which leads to reduced appetite and increased energy expenditure. Elite Pharmaceuticals manufactures and distributes generic Phendimetrazine Tartrate 35 mg tablets, which are a generic equivalent of Bontril PDM®.

Brand names
Bontril PDMAdipostAnorex-SRAppeconBontril Slow ReleaseMelfiatObezinePhendietPleginePrelu-2Prelu2Prelu 2Statobex
Other names
Phendimetrazine TartrateMephenmetrazine(2S,3S)-3,4-Dimethyl-2-phenylmorpholine
02

Targets

SERT (Sodium-dependent serotonin transporter)DAT (Dopamine plasma membrane transport protein)NET (Norepinephrine Transporter)ADRA1A (α1A)

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