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Phenocaine Plus
- Development stage
- Unknown
- Lead developer
- Entod Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
Phenocaine Plus is a sterile, preservative-free intracameral injectable solution developed by Entod Pharmaceuticals for use in ophthalmic procedures, particularly cataract surgery. It is a fixed-dose combination of three active ingredients: lidocaine hydrochloride (a local anesthetic), phenylephrine hydrochloride (an alpha-1 adrenergic receptor agonist), and tropicamide (a muscarinic receptor antagonist). When administered intracamerally at the beginning of cataract surgery, Phenocaine Plus provides rapid and sustained intraocular anesthesia while simultaneously inducing and maintaining stable pupillary dilation (mydriasis) and cycloplegia. This combination eliminates the need for multiple preoperative dilating eye drops, thereby simplifying the surgical workflow, reducing ocular surface toxicity, and enhancing patient comfort and safety during the procedure.
- Brand names
- Phenocaine Plus
- Other names
- PhenocanePhenocainelidocaine + phenylephrine + tropicamidetropicamide + phenylephrine + lidocaine
02
Targets
ADRA1A (α1A)mAChR (Muscarinic acetylcholine receptors)NaV (Voltage-gated sodium channels)
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