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Phenolsulfonphthalein, also known as phenol red or PSP, is a synthetic small molecule used primarily as a diagnostic agent to assess kidney function. It is administered by injection and its excretion in urine is measured to evaluate renal plasma flow and overall kidney performance. The compound acts as a pH indicator in laboratory settings due to its color change properties across different pH ranges. Clinically, it has been investigated for weak estrogen-mimicking actions and has demonstrated the ability to inhibit amyloid fibril formation in vitro. Its use as a diagnostic tool has largely been replaced by more modern methods but may still be encountered in specific clinical or research contexts[1][2][3][4][6][8].
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