Drug intelligence / Profile preview

phentermine

Development stage
Approved
Lead developer
KVK Tech
Modality
Small Molecules
Administration
Oral
01

Overview

Phentermine is a sympathomimetic amine and appetite suppressant used as a short-term adjunct in the management of obesity. It is typically prescribed for individuals who are overweight or obese and have not achieved sufficient weight loss with diet and exercise alone. Phentermine acts primarily by stimulating the central nervous system to increase norepinephrine release in the lateral hypothalamus, which suppresses appetite. It may also increase dopamine levels and weakly affect serotonin reuptake. The drug was first introduced in 1959 and remains one of the most commonly prescribed anti-obesity medications. Phentermine is available as oral tablets or capsules under several brand names[1][7][8].

Brand names
Adipex-PLomairaDuromineSuprenza
Other names
α-methylamphetamineα-α-dimethylphenethylamine
02

Targets

DAT (Dopamine plasma membrane transport protein)NET (Norepinephrine Transporter)ADRB2 (β2)

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