phenylbutazone

Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-inflammatory properties. It acts primarily by inhibiting cyclooxygenase (COX), thereby reducing the synthesis of prostaglandins and other mediators involved in inflammation and pain. Originally introduced for human use in the late 1940s to treat conditions such as rheumatoid arthritis, ankylosing spondylitis, gout, and osteoarthritis[1][2][5], it has since been withdrawn from most human markets due to serious adverse effects including bone marrow suppression and aplastic anemia[4][5]. Today it is widely used in veterinary medicine—especially for horses—to manage musculoskeletal pain (lameness), soft-tissue injuries, arthritis-related inflammation, and fever[6][7][8]. In animals it can be administered orally or intravenously.

Brand names

ButazolidineEquizonePhenylbuteButatronButequine

Other names

bute3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione4-n-butyl-1,2-diphenyl-pyrazolidinedioneFenilbutazonaPhenbutazonePhenylbutazonum