phenylcapsaicin

Phenylcapsaicin is a synthetic analog of capsaicin, the active compound in chili peppers. It is designed to have higher bioavailability and stability compared to natural capsaicin[1][8]. Phenylcapsaicin acts as an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor, also known as the "capsaicin receptor," which plays roles in pain perception, thermoregulation, and metabolic processes[2][6][7]. Research indicates that phenylcapsaicin can enhance fat oxidation during aerobic exercise, improve strength performance, reduce muscle damage and perceived exertion during resistance training, and may support weight management by increasing metabolism and reducing energy intake[1][3][4][6]. Additionally, it has been shown to lower serum zonulin levels—suggesting improved gut barrier function—and inhibit bacterial quorum sensing in the gut microbiome[6][8]. The primary developer and manufacturer is aXichem; its commercial product name is aXivite[4].

Brand names

aXivite

Other names

phenylcapsaicin