phenylephrine + chlorpheniramine + dextromethorphan

**Phenylephrine + chlorpheniramine + dextromethorphan** is a combination medication primarily used for the temporary relief of symptoms associated with the common cold, hay fever, and other upper respiratory allergies, including cough, runny or stuffy nose, sneezing, itching, and watery eyes[1][7]. **Mechanism of Action:** - **Phenylephrine** is a nasal decongestant that works by shrinking swollen nasal membranes, thereby decreasing blood flow to the swollen areas and allowing easier breathing[1]. - **Chlorpheniramine** is an antihistamine that reduces the effects of histamine, a natural chemical responsible for allergy symptoms like sneezing, itching, watery eyes, and runny nose[1]. - **Dextromethorphan** is a non-opioid cough suppressant that acts on the cough center in the brain to reduce the urge to cough[1]. This combination is available in liquid, syrup, and tablet forms and is intended for oral administration[1][5]. It is typically indicated for adults and children above a certain age, often 6 to 12 years, with specific dosing instructions for different age groups[5]. **Precautions:** - Contraindicated in patients with breathing problems (e.g., asthma, emphysema), heart disease, high blood pressure, glaucoma, thyroid disease, diabetes mellitus, or difficulty urinating due to an enlarged prostate gland[1][5]. - Should not be used with monoamine oxidase inhibitors (MAOIs), sedatives, or certain antidepressants[1][5]. - May cause drowsiness, dry mouth, headache, nervousness, nausea, vomiting, and other side effects[1][2]. - Not recommended during pregnancy or breastfeeding without medical advice[1]. - Avoid alcohol and activities requiring alertness due to potential drowsiness[1][5]. **Lifestyle Recommendations:** - Stay hydrated, use a humidifier, avoid respiratory irritants, and maintain hand hygiene to support symptom management[1].

Brand names

ED A-HIST DM

Other names

phenylephrine + chlorpheniramine maleate + dextromethorphan hydrobromidechlorpheniramine + dextromethorphan + phenylephrine hydrochloridechlorpheniramine, dextromethorphan, and phenylephrine