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Phenylephrine + Nicardipine + Labetalol + Urapidil

Development stage
Unknown
Lead developer
Johnson & Johnson Consumer Inc. (J&JCI)
Modality
Device-based Delivery → Drug Delivery Systems
Administration
Intravenous, Oral
01

Overview

This combination refers to a collection of four distinct antihypertensive medications: phenylephrine, nicardipine, labetalol, and urapidil. These drugs are typically used individually or in various subsets to manage hypertension, particularly in emergency or acute settings, rather than being formulated together as a single combination drug product. Phenylephrine is an alpha-1 agonist causing vasoconstriction. Nicardipine is a calcium channel blocker causing vasodilation. Labetalol is a combined alpha and beta blocker. Urapidil is an alpha-1 antagonist and serotonin receptor agonist. While individual components or subsets of this group are standard treatments for conditions like hypertensive emergencies, peripartum hypertension, and acute stroke, the specific combination of all four is not described as a standard treatment protocol.

02

Targets

CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)ADRA1 (Alpha-1 adrenergic receptor family)ADRB1 (β1)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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