phenylsuccinic acid

Phenylsuccinic acid (often referred to as phenylsuccinate) is a dicarboxylic acid derivative that acts as a competitive inhibitor of mitochondrial transport carriers, specifically the dicarboxylate carrier (DIC; SLC25A10) and the oxoglutarate carrier (OGC; SLC25A11). By blocking these carriers, phenylsuccinic acid inhibits the malate-aspartate shuttle, which is essential for transferring reducing equivalents (NADH) from the cytosol into the mitochondrial matrix. In pancreatic islet research, it has been utilized to study metabolic coupling, demonstrating that inhibition of the malate-aspartate shuttle selectively abolishes glucose-provoked glucagon secretion from alpha-cells without affecting insulin secretion from beta-cells. It is primarily employed as a research-use-only laboratory tool to investigate mitochondrial transport, cellular respiration, and metabolic pathways.

Other names

2-phenylbutanedioic acid2-phenylsuccinate2-phenylsuccinic acidphenyl succinatephenylsuccinate