phenyltoloxamine

Phenyltoloxamine is a first-generation antihistamine of the ethanolamine class with sedative and mild analgesic effects. It acts as an H1 receptor antagonist and is primarily used to treat symptoms of the common cold (such as sneezing, cough, runny nose, watery eyes), allergies (allergic rhinitis and conjunctivitis), and as a short-acting sedative. Due to its central nervous system penetration and tranquilizing properties, it is also used in combination with other agents like acetaminophen or codeine for enhanced analgesia or antitussive effect. Phenyltoloxamine stabilizes mast cells by lowering intracellular calcium levels and reduces inflammatory responses by inhibiting NF-kB signaling pathways[1][2][5][6]. It is most commonly found in over-the-counter combination products for relief of minor aches/pains associated with colds or allergies.

Brand names

DologesicRelagesicPercogesicMajor-gesicPhenylgesic

Other names

phenyltoloxamine hydrochloridephenyltoloxamine citrate