Phleum pratense pollen extract

Alutard grass pollen (marketed under the brand name Alutard SQ Phleum pratense) is an aluminum hydroxide-adsorbed, depot allergen immunotherapy vaccine derived from *Phleum pratense* (timothy grass pollen), developed and manufactured by ALK-Abelló. It is indicated for the treatment of IgE-mediated allergic rhinitis and allergic rhinoconjunctivitis in patients sensitized to grass pollen. The vaccine works by gradually desensitizing the immune system to grass pollen allergens, shifting the immune response from a Th2-dominated allergic pathway to a Th1/regulatory T-cell (Treg) response, which reduces allergen-specific IgE and increases blocking IgG4 antibodies. While traditionally administered via subcutaneous injection (SCIT), it has also been investigated in clinical trials (such as a Phase 3 trial by HagaZiekenhuis) via a novel intralymphatic/intranodal route of administration to improve efficacy and convenience.

Brand names

Alutard SQAlutard SQ Phleum pratenseAlutard SQ TimotejAlutard SQ Timotei

Other names

Alutard grass pollentimothy grass pollen extractPhleum pratense allergen extract