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phlomis umbrosa water extract
- Development stage
- Preclinical
- Lead developer
- Naturalendo Tech
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Phlomis umbrosa water extract (PUW) is a botanical extract derived from the roots of *Phlomis umbrosa Turcz.*, a perennial herb traditionally used in East Asian medicine. It is primarily investigated in preclinical research for its potential therapeutic effects on muscle atrophy, osteoporosis, and osteoarthritis. The extract functions by regulating the PI3K/Akt/mTOR signaling pathway, which helps attenuate dexamethasone-induced muscle atrophy by maintaining muscle mass and strength while decreasing protein degradation. PUW contains various bioactive compounds, including iridoid glycosides (such as shanzhiside methyl ester), flavonoids, and polyphenols. While not developed as a standalone pharmaceutical drug, it is a key component of EstroG-100®, a patented herbal product used for treating menopausal symptoms.
- Other names
- Phlomis umbrosa root extractPhlomis umbrosa Turcz. water extract
02
Targets
mTOR (Mammalian target of rapamycin kinase)AKT (RAC-alpha serine/threonine-protein kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
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