Drug intelligence / Profile preview

phloroglucinol + simeticone

Development stage
Unknown
Lead developer
Alfasigma
Modality
Small Molecules
Administration
Oral
01

Overview

Météoxane is a fixed-dose combination small-molecule drug developed by Laboratoires IPRAD for the symptomatic treatment of functional intestinal disorders and irritable bowel syndrome (IBS). It consists of two active ingredients: phloroglucinol (80 mg), a non-atropinergic antispasmodic that acts directly on gastrointestinal smooth muscle to relieve spasms, and simeticone (125 mg), an antiflatulent that modifies the surface tension of gas bubbles in the digestive tract to facilitate their dispersion. The drug is primarily indicated for symptoms such as bloating, flatulence, and abdominal pain. It is available over-the-counter in France as oral capsules and has been evaluated in Phase 4 clinical trials for the management of painful exacerbations in patients with IBS.

Brand names
Météoxane
Other names
Meteoxane
02

Targets

Gastrointestinal luminal gas bubbles and foamCaV3 (Caveolin-3)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)

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