Drug intelligence / Profile preview

PHmiR-SM101X

Development stage: Preclinical
Lead developer: Pharmahungary Group
Modality: RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intravenous

Overview

PHmiR-SM101X is a microRNA-based therapeutic candidate (ProtectomiR) being developed for cardioprotection against ischemia-reperfusion injury following acute myocardial infarction. Identified in a translational large-animal model of myocardial infarction, PHmiR-SM101X has demonstrated dose-dependent cardioprotective effects in neonatal rat cardiomyocytes and human AC16 cells under simulated ischemia-reperfusion conditions. Bioinformatic analyses indicate that PHmiR-SM101X modulates gene networks involved in survival and stress signaling pathways, with predicted targets including SMAD2, DAPK2, and SOD2, implicating TGF-beta signaling, apoptosis, and redox regulation. It is being evaluated with polymer-based and lipid nanoparticle (LNP) delivery systems to optimize myocardial uptake.

Targets

DNM1L (Dynamin-related protein 1)SMAD2 (Mothers against decapentaplegic homolog 2)Misfolded SOD1

Beyond the preview

Go deeper on PHmiR-SM101X.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on PHmiR-SM101X.