Drug intelligence / Profile preview

PHNO

Development stage
Preclinical
Modality
Small Molecules
Administration
Intravenous
01

Overview

(+)-PHNO is a synthetic dopamine receptor agonist primarily used in research settings. It acts as a potent and selective agonist at the dopamine D2 and D3 receptors, with higher affinity for the D3 subtype. PHNO is not approved for clinical use but is widely utilized in neuroimaging studies (such as PET scans) to investigate dopaminergic function in the brain. Its mechanism of action involves mimicking dopamine by binding to and activating these receptors, which are implicated in various neurological and psychiatric conditions including Parkinson's disease and schizophrenia.

Other names
(+)-4-propyl-9-hydroxynaphthoxazine(+)-PHNOR-(+)-7-OH-PIPAT
02

Targets

DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)

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