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(+)-PHNO is a synthetic dopamine receptor agonist primarily used in research settings. It acts as a potent and selective agonist at the dopamine D2 and D3 receptors, with higher affinity for the D3 subtype. PHNO is not approved for clinical use but is widely utilized in neuroimaging studies (such as PET scans) to investigate dopaminergic function in the brain. Its mechanism of action involves mimicking dopamine by binding to and activating these receptors, which are implicated in various neurological and psychiatric conditions including Parkinson's disease and schizophrenia.
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