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Phoenix dactylifera seeds methanol extract is an extract obtained from the seeds of the date palm (Phoenix dactylifera) using methanol as a solvent. The extract is a source of various **phenolic compounds** (including catechic tannins, naringenin, rutin, and ferulic acid) and exhibits significant **antioxidant properties**[1][2][5]. Studies have demonstrated that this extract can scavenge free radicals and chelate iron ions, showing potential as a natural antioxidant source[1][4][5]. There is also evidence for additional **biological effects**: in vitro, the extract showed **anti-leukemic activity** against acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML) cells, with cytotoxicity comparable to standard chemotherapy drugs under certain conditions[3]. Further, it has been reported to **attenuate melanogenesis** in melanoma cells by downregulating PKA signaling pathways, indicating potential as a skin-whitening agent[4]. These properties are attributed to the extract's rich **polyphenol and flavonoid content**, which provide antioxidant, anti-inflammatory, anticancer, and skin-protective effects[1][2][4][5].
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