Drug intelligence / Profile preview

phosmet

Development stage
Unknown
Lead developer
Gowan Company
Modality
Small Molecules
Administration
Topical
01

Overview

Phosmet is a non-systemic, phthalimide-derived organophosphate insecticide and acaricide primarily used in agriculture to control a wide range of insect pests on fruit crops (notably apple trees for codling moth), ornamentals, vines, and also on animals for lice, fleas, and ticks. Its mechanism of action involves competitive inhibition of acetylcholinesterase and pseudocholinesterase enzymes in target organisms. This inhibition prevents the breakdown of acetylcholine at nerve synapses, leading to accumulation of the neurotransmitter and subsequent overstimulation of the nervous system[1][6][10]. Phosmet is classified as moderately toxic (EPA toxicity class II) and has been registered for use since the mid–1960s[1][7].

Brand names
ImidanProlate EProlate 5 DustProlate5 DustProlate-5 DustProlate 8-OSProlate8-OSProlate-8-OSImidan WPImidan 5 DustImidan5 DustImidan-5 Dust
Other names
phosmetFosmetDecemthionPhthalophosImidathionPercolateFtalophosKemolateSafidonSimidanSmidanDecemthion P–6PMP (Pesticide)PhtalofosStauffer R 1504O,O-Dimethyl S-phthalimidomethyl phosphorodithioateO,O-Dimethyl phthalimidomethyl phosphorodithioateCaswell No. 543O,O-Dimethyl S-(phthalimidomethyl) dithiophosphatePhthalimido O,O-dimethyl phosphorodithioatePHOSPHORODITHIOIC ACID, O,O-DIMETHYL S-PHTHALIMIDOMETHYL ESTERappaPoronDel–Phos
02

Targets

AcetylcholinesteraseButyrylcholinesterase

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