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Phosmet is a non-systemic, phthalimide-derived organophosphate insecticide and acaricide primarily used in agriculture to control a wide range of insect pests on fruit crops (notably apple trees for codling moth), ornamentals, vines, and also on animals for lice, fleas, and ticks. Its mechanism of action involves competitive inhibition of acetylcholinesterase and pseudocholinesterase enzymes in target organisms. This inhibition prevents the breakdown of acetylcholine at nerve synapses, leading to accumulation of the neurotransmitter and subsequent overstimulation of the nervous system[1][6][10]. Phosmet is classified as moderately toxic (EPA toxicity class II) and has been registered for use since the mid–1960s[1][7].
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