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phosphoaminophosphonic acid guanylate ester
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
Phosphoaminophosphonic acid guanylate ester is a synthetic, non-hydrolyzable analog of guanosine triphosphate (GTP), in which the oxygen atom bridging the beta and gamma phosphate groups is replaced by a nitrogen atom. This modification confers resistance to hydrolysis, making it useful as a biochemical tool for studying G-protein signaling pathways. The compound binds tightly to G-proteins in the presence of magnesium ions and acts as a potent stimulator of adenylate cyclase, leading to increased cyclic AMP production. It is primarily used in research settings to investigate mechanisms involving GTP-binding proteins and signal transduction processes[1][2][3][9].
- Other names
- 5'-guanylylimidodiphosphateguanosine 5'-[beta,gamma-imido]triphosphateguanylyl imidodiphosphatephosphoaminophosphonic acid-guanylate ester
02
Targets
AC (Adenylyl cyclase family)Gα (G-protein α subunits)
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