Drug intelligence / Profile preview

Phosphoenolpyruvate

Development stage
Preclinical
Modality
Small Molecules
Administration
Intravenous
01

Overview

Phosphoenolpyruvate (PEP) is a high-energy phosphate compound and a crucial intermediate metabolite involved in glycolysis and gluconeogenesis. It plays a vital role in cellular energy metabolism, particularly in the production of adenosine triphosphate (ATP). Investigations have explored its therapeutic potential, demonstrating its ability to protect against ischemia-reperfusion injury and aid in organ preservation by recovering hepatic energy and preventing ATP decline. Additionally, Phosphoenolpyruvate exhibits cytoprotective and anti-oxidative properties, including the reduction of reactive oxygen species.

Other names
2-phosphoenolpyruvatePhosphoenolpyruvic acid
02

Targets

PEPCK (Phosphoenolpyruvate carboxykinase 1)PK (Pyruvate kinase)

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