phosphoramidon

Phosphoramidon is a small molecule dipeptide inhibitor derived from the bacterium Streptomyces tanashiensis. It acts as a potent and reversible inhibitor of several zinc metallopeptidases including neprilysin (neutral endopeptidase 24.11), neprilysin 2, thermolysin, and endothelin-converting enzyme (ECE-1). By inhibiting these enzymes—especially neprilysin—it prevents the degradation of various bioactive peptides such as bradykinin and enkephalins. Phosphoramidon is widely used as a biochemical tool in research to study peptidase function and peptide metabolism but is not approved for clinical use[1][2][3][6][8].

Other names

phosphoramidon disodium saltN-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophanPhosporamidonPhosphramidon