photocyanine

Photocyanine is a novel, amphiphilic zinc-substituted phthalocyanine photosensitizer developed by researchers at Fuzhou University for use in photodynamic therapy (PDT). It is composed of a mixture of four cis-isomers of a sulfonated and phosphonated zinc phthalocyanine (ZnPcS2P2). The drug is designed to selectively accumulate in tumor tissues following intravenous administration. Upon excitation with a 670 nm laser, Photocyanine generates reactive oxygen species (ROS), particularly singlet oxygen, which induces targeted cell death. Its mechanism of action involves the reduction of mitochondrial membrane potential, activation of caspase-3, and induction of cell cycle arrest at the G2/M stage, leading to apoptosis and necrosis. Clinical investigations in China have evaluated Photocyanine for the treatment of various malignancies, including skin cancer, esophageal cancer, and hepatocellular carcinoma.

Other names

zinc phthalocyanine derivativeZnPcS2P2ZnPcS-2P2ZnPcS 2P2photocyanine injection