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PHOX2B epitope-encoded mRNA-LNP vaccine
- Development stage
- Preclinical
- Lead developer
- Children's Hospital of Philadelphia
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The PHOX2B epitope-encoded mRNA-LNP vaccine is an investigational cancer vaccine designed as a 'CAR boosting' strategy to enhance the persistence and anti-tumor potency of peptide-centric chimeric antigen receptor (PC-CAR) T cells. The vaccine consists of nucleoside-modified mRNA encoding a 9mer peptide monomer derived from the PHOX2B oncoprotein, encapsulated in the FDA-approved SM-102 lipid nanoparticle (LNP). PHOX2B is a major neuroblastoma oncoprotein, and this vaccine specifically targets the epitope presented in the context of HLA-A*24:02. By treating monocyte-derived dendritic cells (moDCs), the vaccine induces high-level antigen presentation and upregulates T cell costimulatory ligands such as CD80/86 and CD40. This process stimulates the proliferation, polyfunctionality, and memory formation of PC-CAR T cells, helping to overcome the hostile tumor immune microenvironment and poor persistence typically associated with adoptive cellular therapies in solid tumors like neuroblastoma.
- Other names
- PHOX2B epitope mRNA-LNP vaccinePHOX-2B epitope mRNA-LNP vaccinePHOX 2B epitope mRNA-LNP vaccinePHOX2B 9mer mRNA-LNP vaccinePHOX-2B 9mer mRNA-LNP vaccinePHOX 2B 9mer mRNA-LNP vaccinePHOX2B epitope-encoded mRNA-LNP vaccinePHOX-2B epitope-encoded mRNA-LNP vaccinePHOX 2B epitope-encoded mRNA-LNP vaccine
02
Targets
PHOX2B (Paired-like homeobox 2b protein)
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