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**PHR160** is an Iranian herbal inhalation spray developed for COVID-19-associated lung injury and respiratory impairment, including improvement of oxygen saturation. It is a chemically heterogeneous herbal formulation reported to contain cineole, menthol, saffron, safranal, and crocin. Product information describes CFTR activation as its proposed mechanism, intended to support airway-surface hydration through the cAMP-regulated chloride channel. PHR160 has been evaluated in multicenter randomized, blinded clinical studies in patients with COVID-19, including ClinicalTrials.gov study NCT04463420 sponsored by Baqiyatallah University of Medical Sciences. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04463420))
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