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Phtalox is a phthalocyanine derivative, specifically iron tetracarboxyphthalocyanine, utilized primarily in dental and oral care applications. It functions as a photosensitizer and catalyst that generates reactive oxygen species (ROS), such as singlet oxygen and superoxide, which exhibit broad-spectrum antimicrobial, anti-inflammatory, and deodorizing properties. In clinical practice, Phtalox is formulated as a mouthwash or oral gel and used as an adjuvant in the treatment of periodontal diseases like periodontitis, assisting in the control of pathogenic biofilms during scaling and root planing. Beyond periodontology, it has been explored for its potential in preventing the progression of COVID-19 and as an experimental agent in teeth whitening formulations due to its oxidative and optical characteristics.
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