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Phylex bivalent vaccine
- Development stage
- Preclinical
- Lead developer
- Phylex BioSciences
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Phylex bivalent vaccine is an investigational second-generation **mRNA-based COVID-19 vaccine** being developed by Phylex BioSciences as a booster candidate. The vaccine is described as a **bivalent** formulation directed against the **Delta and Omicron variants of SARS-CoV-2** and uses mRNA encoding a **self-assembling nanoparticle** that displays multiple copies of the viral **receptor-binding domain** antigen. Its intended mechanism is to induce neutralizing immune responses against the SARS-CoV-2 spike receptor-binding domain, thereby blocking viral interaction with **ACE2** and helping prevent COVID-19 caused by targeted variants, while the design goal also includes reducing antibodies that could enhance infection.
- Other names
- Phylex bivalent vaccine
02
Targets
SARS-CoV-2 spike
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