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Phyllanthus amarus leaf extract
- Development stage
- Unknown
- Lead developer
- Biotropics Malaysia
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Phyllanthus amarus leaf extract is a botanical extract derived from the leaves of the tropical herb Phyllanthus amarus (family Phyllanthaceae/Euphorbiaceae). It contains bioactive phytochemicals including lignans (such as phyllanthin and hypophyllanthin), flavonoids (such as quercetin and rutin), and ellagitannins. The extract is traditionally used for hepatoprotection, antiviral activity (particularly against hepatitis B virus), and anti-inflammatory effects. Standardized formulations, such as PHYLLPRO, have been clinically evaluated for the relief of alcohol-induced hangover symptoms and protection against oxidative stress. Additionally, preclinical research has demonstrated its antibacterial potential against multidrug-resistant (MDR) pathogens, including Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus, potentially through the inhibition of bacterial DNA gyrase B.
- Brand names
- PHYLLPRO
- Other names
- Phyllanthus amarus extractPhyllanthus amarus leaf extractsPhyllanthus amarus leaves extractaqueous Phyllanthus amarus leaf extractstandardized ethanol extract of Phyllanthus amarus leaves
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)GyrB (DNA gyrase subunit B)HBV Pol (Hepatitis B virus polymerase)
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