phyllanthus niruri + boerhaavia diffusa + picrorhiza kurroa

This is a combination herbal preparation comprising **phyllanthus niruri**, **boerhaavia diffusa**, and **picrorhiza kurroa**—three botanicals widely used in Ayurvedic and traditional medicines for hepatoprotective, nephroprotective, immunomodulatory, anti-inflammatory, and antioxidant properties. - **Phyllanthus niruri**: Traditionally used for **urinary tract health** (antiurolithic), hepatoprotection, and relief in digestive disorders. Its mechanism involves inhibition of stone formation via modulation of calcium oxalate crystallization, antioxidative action, and mild diuretic effect. Some data suggest immunomodulatory and mild antimicrobial effects, but evidence remains limited[3]. - **Boerhaavia diffusa**: Used as a **diuretic, hepatoprotective, anti-inflammatory, and immunomodulatory** agent. Its bioactives (notably boeravinone compounds and punarnavine alkaloids) modulate cellular signaling (inhibition of NF-κB), enhance renal blood flow, provide antioxidant and anti-inflammatory effects, and regulate immune cell function, both stimulating and suppressing various immune cells depending on context[1]. - **Picrorhiza kurroa**: Extensively used for **liver disorders, inflammation, and immune regulation**. Rich in iridoid glycosides (especially kutkin, picrosides), it exerts **hepatoprotective, anti-inflammatory (modulating NF-κB), antioxidant, antidiabetic, and immunomodulatory** effects. It inhibits pro-inflammatory cytokines and is used in traditional medicine for digestive, hepatic, and some autoimmune conditions[2][4]. This **polyherbal combination** is generally formulated for comprehensive liver support, nephroprotection, or immunomodulation, but scientific evidence for synergistic efficacy and safety is limited. The combination works via multi-target effects: antioxidant activity, modulation of pro- and anti-inflammatory cytokines (such as TNF-α, IL-1β, IL-10), enhancement of cellular immune response, inhibition of inflammatory signaling (primarily NF-κB), and improved regeneration/repair mechanisms in hepatic and renal cells[1][2].