physalis angulata extract

*Physalis angulata* extract is a botanical substance derived from the Cutleaf Groundcherry plant, highly valued in dermatology for its concentration of **physalins**, which are naturally occurring secosteroids. It exhibits potent anti-inflammatory, antioxidant, and skin-soothing properties, often marketed as having a "corticosteroid-like" efficacy without the side effects associated with synthetic steroids, such as skin thinning or atrophy. The extract works by modulating the production of inflammatory mediators, specifically inhibiting the **NF-κB** signaling pathway and reducing the levels of pro-inflammatory cytokines like **TNF-α** and **IL-6**. It is primarily utilized in topical formulations to promote wound healing, accelerate re-epithelialization, and treat conditions characterized by erythema and skin sensitivity. It has been investigated in combination products (such as Ready Medical Post Treatment) to improve recovery after surgical procedures like split-thickness skin grafting.

Brand names

Physavie

Other names

Cutleaf groundcherry extractCamapu extractPhysalis angulata L. extract