Drug intelligence / Profile preview

Physio-L

Development stage
Unknown
Lead developer
Senju Pharmaceutical
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

Physio-L is a sterile, intraocular irrigating solution specifically formulated for use during ophthalmic surgeries, such as cataract extraction and vitrectomy. Developed by Senju Pharmaceutical, it serves as a physiological replacement for the natural aqueous humor, which is often depleted or replaced during surgical maneuvers. The solution contains a balanced blend of essential electrolytes—including sodium chloride, potassium chloride, calcium chloride, and magnesium chloride—along with sodium acetate, sodium citrate, and glucose. These components work synergistically to maintain the osmotic balance and provide metabolic support to the corneal endothelial cells and other intraocular tissues. By preserving the integrity of the corneal endothelium, Physio-L helps prevent postoperative corneal edema and ensures better visual outcomes for patients undergoing complex or lengthy ocular procedures.

Brand names
Physio-L
Other names
Physio-L Intraocular Irrigating Solution
02

Targets

ROCK1 (Rho-associated coiled-coil containing protein kinase 1)ROCK2 (Rho-associated coiled-coil containing protein kinase 2)

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