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physiological saline

Development stage: Unknown
Lead developer: GSK
Modality: Small Molecules
Administration: Intramuscular

Overview

Physiological saline is a sterile solution of 0.9% sodium chloride (NaCl) in water, commonly used as an inert placebo comparator in clinical trials. In the context of GlaxoSmithKline's (GSK) development of the M72/AS01E tuberculosis vaccine candidate, this saline solution was utilized as a blinded control to assess the safety and immunogenicity of the vaccine in HIV-positive adults. As a placebo, it lacks an active pharmaceutical ingredient, biological target, or therapeutic mechanism of action, serving solely to provide a baseline for comparison against the active vaccine and its adjuvant components.

Other names: normal saline0.9% NaCl solutionsaline controlcontrol vaccine with physiological saline

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